Skating on Thin Intermediation: Can Libraries Survive?

Skating on thin ice: pragmatic prescribing for medication refractory schizophrenia

BACKGROUND Clozapine is the treatment of choice for medication refractory psychosis, but it does not benefit half of those put on it. There are numerous studies of potential post-clozapine strategies, but little data to guide the order of such treatment in this common clinical challenge. We describe a naturalistic observational study in 153 patients treated by a specialist psychosis service to ...

Blocking platelets more: are we skating on thin ice?

Can England's NHS survive?

n engl j med 369;1 nejm.org july 4, 2013 1 a crisis that can be resolved only by altering the fundamental principle on which it was founded — provision of funding from general taxation, with care being free at the point of use. Although the criticism was sparked by a February report on an inquiry into shortcomings at one hospital,1 the problems originated in 2010, when two profound forces were ...

Mesenchymal stem cells can survive on the extracellular matrix-derived decellularized bovine articular cartilage scaffold

Objective (s): The scarcity of articular cartilage defect to repair due to absence of blood vessels and tissue engineering is one of the promising approaches for cartilage regeneration. The objective of this study was to prepare an extracellular matrix derived decellularized bovine articular cartilage scaffold and investigate its interactions with seeded rat bone marrow mesenchymal stem cells (...

Can cognition survive heart surgery?

In this issue of Circulation, Jensen et al 1 report that cognitive difficulties were no fewer when off-pump (OPCAB) versus conventional (CCAB) coronary artery bypass grafting was used. This important investigation, a substudy of the Best Bypass Surgery Trial, is a randomized prospective controlled trial that compares OPCAB with CCAB. Although the numbers seem relatively small (ie, 120 elderly p...